Diabetes is a worldwide epidemic that has led to a rise in diabetic kidney disease (DKD). Over the past two decades, there has\nbeen significant clarification of the various pathways implicated in the pathogenesis of DKD. Nonetheless, very little has changed\nin the way clinicians manage patients with this disorder. Indeed, treatment is primarily centered on controlling hyperglycemia and\nhypertension and inhibiting the renin-angiotensin system. The purpose of this review is to describe the current understanding of\nhow the hemodynamic, metabolic, inflammatory, and alternative pathways are all entangled in pathogenesis of DKD and detail the\nvarious therapeutic targets that may one day play a role in quelling this epidemic.
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